Oxygen sensing by ion channels
نویسندگان
چکیده
منابع مشابه
Regulation of oxygen sensing by ion channels.
O(2) sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or physiological conditions. O(2)-sensitive ion channels are major effectors of the cellular responses to hypoxia. These channels are preferentially found in excitable neurosecretory cells (glomus cells of the carotid body, cells in the neuroepithelial bodies of the lung, and neo...
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pAper type 290 Channels Volume 8 Issue 4 AutoCommentAry A decrease in arterial O 2 pressure (pO 2) elicits a peripheral chemosensory reflex that increases ventilation and sympathetic nerve activity. This reflex is initiated at the carotid body glomus (Type 1) cells where the reduced pO 2 alters the activities of various ion channels and causes cell depolarization. The depolarization opens the v...
متن کاملInvited Review HIGHLIGHTED TOPIC Oxygen Sensing in Health and Disease Regulation of oxygen sensing by ion channels
López-Barneo, José, Raquel del Toro, Konstantin L. Levitsky, Marı́a D. Chiara, and Patricia Ortega-Sáenz. Regulation of oxygen sensing by ion channels. J Appl Physiol 96: 1187–1195, 2004; 10.1152/japplphysiol.00929.2003.—O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or physiological conditions. O2-sensitive ion channels are maj...
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Acetylcholine is a neurotransmitter synthesized from choline and acetyl coenzyme A. It is localized in large reticular formation neurons, and is the chemical mediator in the synapse of a motor endplate. The electrical signal of the motor nerve terminal causes release of many packets of acetylcholine. The packets are released into the synaptic cleft, where receptors in the postjunctional membran...
متن کاملOxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells.
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2-regulated K+ channels. The mechanisms involved in the detection of changes of O2 tension are unknown. Inhibition of the mitochondrial electron transport chain (ETC) at proximal and distal complexes induces external Ca(2+)-dependent catecholamine secretion. At...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1997
ISSN: 0085-2538
DOI: 10.1038/ki.1997.61